Cytogenet Cell Genet. 1993;64(3-4):227-30.

Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus.

Iles DE, Segers B, Weghuis DO, Suikerbuijk R, Wieringa B.

Department of Cell Biology and Histology, Faculty of Medical Sciences, Catholic University of Nijmegen, The Netherlands.

The skeletal muscle dihydropyridine receptor consists of five subunits and fulfils an essential role in excitation-contraction coupling. A genomic clone for the human gamma subunit was used to map the gene (CACNLG) to chromosome band 17q24 by in situ hybridization. Contained within the gene is a 416-bp polymorphic repetitive DNA element that is potentially useful as a genetic marker.

PMID: 8404045 [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Genetic mapping of the beta 1- and gamma-subunits of the human skeletal muscle L-type voltage-dependent calcium channel on chromosome 17q and exclusion as candidate genes for malignant hyperthermia susceptibility.
Hum Mol Genet. 1993 Jul; 2(7):863-8.

[Hum Mol Genet. 1993]
Molecular characterization of the gene encoding the gamma subunit of the human skeletal muscle 1,4-dihydropyridine-sensitive Ca2+ channel (CACNLG), cDNA sequence, gene structure, and chromosomal location.
J Biol Chem. 1993 May 5; 268(13):9275-9.

[J Biol Chem. 1993]
Exclusion of malignant hyperthermia susceptibility (MHS) from a putative MHS2 locus on chromosome 17q and of the alpha 1, beta 1, and gamma subunits of the dihydropyridine receptor calcium channel as candidates for the molecular defect.
Hum Mol Genet. 1993 Jul; 2(7):857-62.

[Hum Mol Genet. 1993]
Review[What significance to genotype changes have in diagnosis of malignant hyperthermia?]
Anasthesiol Intensivmed Notfallmed Schmerzther. 1996 Aug; 31(6):334-43.

[Anasthesiol Intensivmed Notfallmed Schmerzther. 1996]
Review[Technics of genetic recombination and the human chromosomal map]
Ann Genet. 1982; 25(2):71-86.

[Ann Genet. 1982]
» See reviews... | » See all...

Cited by 1 PubMed Central article

Identification of three novel Ca(2+) channel gamma subunit genes reveals molecular diversification by tandem and chromosome duplication.
Burgess DL, Davis CF, Gefrides LA, Noebels JL. Genome Res. 1999 Dec; 9(12):1204-13.

[Genome Res. 1999]

All links from this record

Related Articles
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene
Gene records that cite the current articles. Citations in Gene are added manually by NCBI or imported from outside public resources.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
HomoloGene
HomoloGene clusters of homologous genes and sequences that cite the current articles. These are references on the Gene and sequence records in the HomoloGene entry.
Nucleotide
Primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Nucleotide (RefSeq)
NCBI nucleotide Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (RefSeq)
NCBI protein Reference Sequences (RefSeqs) that are cited in the current articles, included in the corresponding Gene Reference into Function, or that include the PubMed articles as references.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
UniGene
UniGene clusters of expressed sequences that are associated with the current articles through references on the clustered sequence records and related Gene records.
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
GEO Profiles
Gene Expression Omnibus (GEO) Profiles of molecular abundance data. The current articles are references on the Gene record associated with the GEO profile.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium ...Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus.
Inflammatory cells and bone loss in rheumatoid arthritis.Inflammatory cells and bone loss in rheumatoid arthritis.
Guidelines for the diagnosis and management of hereditary spherocytosis.Guidelines for the diagnosis and management of hereditary spherocytosis.
Primary endodermal sinus tumor presenting with spinal cord compression. Case report.Primary endodermal sinus tumor presenting with spinal cord compression. Case report.
A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type...A homozygous mutation in the endothelin-3 gene associated with a combined Waardenburg type 2 and Hirschsprung phenotype (Shah-Waardenburg syndrome).

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

» See more...

PubMed

Display Settings:

Send to:

Localization of the gamma-subunit of the skeletal muscle L-type voltage-dependent calcium channel gene (CACNLG) to human chromosome band 17q24 by in situ hybridization and identification of a polymorphic repetitive DNA sequence at the gene locus.

Publication Types, MeSH Terms, Substances, Secondary Source ID

Publication Types:

MeSH Terms:

Substances:

Secondary Source ID:

LinkOut - more resources

Other Literature Sources:

Medical:

Libraries:

Supplemental Content

Related articles

Cited by 1 PubMed Central article

All links from this record

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information