Clin Exp Dermatol. 1993 Jul;18(4):305-8.

Protein S deficiency in a patient with necrotizing cellulitis.

Joly P, Chosidow O, Gouault-Heilmann M, Levent M, Roujeau JC, Revuz J.

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Department of Dermatology, Hôpital Henri Mondor, Créteil, France.

Abstract

A case of necrotizing cellulitis of the penis is reported. In this patient, transient functional protein S deficiency during the infectious process was demonstrated with a marked decrease of free protein S and elevated C4b-binding protein levels. Moreover, by investigating other members of this patient's family it was possible to demonstrate a subclinical inherited protein S deficiency. In this study it is suggested that the profound and transient decrease of functional protein S observed in this patient during infectious cellulitis, may have contributed to the pathogenesis of tissue necrosis.

PMID:: 8403462; [PubMed - indexed for MEDLINE]

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Protein S deficiency in a patient with necrotizing cellulitis.

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