Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Drug Des Discov. 1993;9(3-4):299-312.

Novel serotonergic agents.

Author information

  • 1Department of Medicinal Chemistry, School of Pharmacy and Pharmacal Sciences, Purdue University, West Lafayette, Indiana 47907.


The preliminary structure-activity relationships are described for a series of substituted phenethylamines that induce the release of neuronal serotonin. Structures that also have the ability to release neuronal catecholamines are toxic to serotonin neurons, leading to long-term reductions in serotonin markers in rat brain. Conversely, compounds that are selective for the serotonin uptake carrier, and do not affect catecholamines, are not neurotoxic. It is suggested that these novel, selective serotonin releasing agents may find therapeutic utility in disorders where serotonin uptake inhibitors are currently employed.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk