Your browser version may not work well with NCBI's Web applications. More information here...
1: Neuron. 1993 Sep;11(3):423-31.Click here to read Links

Molecular cloning of M6: identification of a PLP/DM20 gene family.

Yan Y, Lagenaur C, Narayanan V.

Department of Neurobiology, School of Medicine, University of Pittsburgh, Pennsylvania.

M6 is a membrane glycoprotein that is expressed on central neurons and certain polarized epithelia from early developmental stage. Antibodies against M6 interfere with cerebellar neurite outgrowth in vitro. Two closely related cDNAs were obtained by expression cloning, both of which showed high homology with the major CNS myelin protein PLP/DM20. Although M6 and PLP/DM20 share many molecular characteristics, in situ hybridization revealed nonoverlapping distributions of their mRNAs in mouse CNS. The identification of a gene family including neuron-specific M6 and glia-specific PLP/DM20 in CNS suggests a broader functional role for these molecules than myelination.

PMID: 8398137 [PubMed - indexed for MEDLINE]