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Immunol Today. 1993 Jun;14(6):326-32.

Donor cell chimerism permitted by immunosuppressive drugs: a new view of organ transplantation.

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  • 1Dept of Surgery, University of Pittsburgh Health Science Center, PA 15213.

Erratum in

  • Immunol Today. 2008 Apr;29(4):149.


One line of thought in organ transplantation feels that immunosuppressive drugs can lead to tolerance induction by allowing a previously unrecognized common mechanism of cell migration and microchimerism to occur, persist, and in some cases, become drug independent. It has been recognized that there is a spectrum of susceptibility of different organs to cellular rejection and that the variable ability of these organs to induce donor-specific nonreactivity reflects their comparative content of migratory leukocytes. Here, Thomas Starzl and colleagues discuss how many of the enigmas of transplantation immunology can be explained by this chimerism.

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