Immunol Today. 1993 Jun;14(6):243-6.

Humanized antibodies.

Source

MRC Laboratory of Molecular Biology, Cambridge, UK.

Erratum in

Immunol Today. 2008 Apr;29(4):149.

Abstract

Hybridoma technology enabled rodent monoclonal antibodies to be created against human pathogens and cells, but these had limited clinical utility. Protein engineering is now generating antibodies for treatment of infectious disease, autoimmune disease and cancer by 'humanizing' rodent antibodies. Humanized antibodies have improved pharmacokinetics, reduced immunogenicity and have been used to clinical advantage.

PMID:: 8397764; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Review

MeSH Terms

Substances

Antibodies, Monoclonal

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Related citations in PubMed

Review Humanized antibodies. [Trends Pharmacol Sci. 1993]
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