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Nature. 1993 Sep 23;365(6444):314-20.

Adrenergic signals direct rhythmic expression of transcriptional repressor CREM in the pineal gland.

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  • 1CNRS URA 1332, Université Louis Pasteur, Strasbourg, France.


Transcription factor CREM appears to play a key physiological and developmental role within the hypothalamic-pituitary-gonadal axis. This axis is modulated by the pineal hormone melatonin, whose production is in turn driven by the endogenous clock. There is striking circadian fluctuation of a novel CREM isoform, ICER, which is expressed at high levels during the night. ICER is generated from an alternative, intronic promoter and functions as a powerful repressor of cyclic AMP-induced transcription. Rhythmic adrenergic signals originated by the clock direct ICER expression by stimulation of the cAMP signal transduction pathway.

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