Cloning and functional expression of a human parat...[Eur J Pharmacol. 1993]

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1: Eur J Pharmacol. 1993 Jul 15;246(2):149-55.Links

Cloning and functional expression of a human parathyroid hormone receptor.

Schneider H, Feyen JH, Seuwen K, Movva NR.

Sandoz Pharma Ltd, Preclinical Research, Basel, Switzerland.

We have cloned a human receptor for parathyroid hormone from a kidney complementary DNA library. The deduced sequence of 593 amino acids shows high homology to the previously cloned receptors from opossum and rat. Expressed in COS-1 cells, the human receptor binds to parathyroid hormone-(1-38) with high affinity (pKD = 8.5) and is functionally coupled to adenylate cyclase (pEC50 = 9.4). At high concentrations of agonist, the receptor also activates phosphoinositide turnover.

PMID: 8397094 [PubMed - indexed for MEDLINE]

Identical complementary deoxyribonucleic acids encode a human renal and bone parathyroid hormone (PTH)/PTH-related peptide receptor. [Endocrinology. 1993]
A G protein-linked receptor for parathyroid hormone and parathyroid hormone-related peptide. [Science. 1991]
Expression of alternatively spliced isoforms of the parathyroid hormone (PTH)/PTH-related peptide receptor messenger RNA in human kidney and bone cells. [Mol Endocrinol. 1996]
ReviewFunctional properties of parathyroid hormone receptors. [Miner Electrolyte Metab. 1982]
ReviewCloning and functional characterization of extracellular Ca(2+)-sensing receptors from parathyroid and kidney. [Bone. 1995]

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Cloning and functional expression of a human parathyroid hormone receptor.

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