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1: Biochem Biophys Res Commun. 1993 Sep 15;195(2):902-9.Click here to read Links

Cloning, functional expression and tissue distribution of human cDNA for the alpha 1C-adrenergic receptor.

Hirasawa A, Horie K, Tanaka T, Takagaki K, Murai M, Yano J, Tsujimoto G.

Department of Molecular, Cell Pharmacology, National Children's Medical Research Center, Tokyo, Japan.

We have cloned human alpha 1C-adrenergic receptor from human prostate cDNA library. The deduced amino acid sequence of the clone (P2C4) encodes a protein of 466 amino acids that showed strong sequence homology to the previously cloned bovine alpha 1C-adrenergic receptor. The radioligand binding properties of P2C4 expressed in COS-7 cells were very similar to those of bovine alpha 1C-adrenergic receptor. With reverse-transcription polymerase chain reaction assay, we observed alpha 1C-adrenergic receptor transcripts in heart, brain, liver and prostate, but not in kidney, lung, adrenal, aorta and pituitary. The data show that the clone P2C4 encodes a human alpha 1C-adrenergic receptor cDNA, and the receptor subtype is expressed not widely but localized in several human tissues.

PMID: 8396931 [PubMed - indexed for MEDLINE]

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