Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Cancer. 1993 Aug 15;72(4):1300-4.

Significance of aneuploid stemlines in testicular nonseminomatous germ cell tumors.

Author information

  • 1Department of Pathology, State University of Groningen, The Netherlands.

Abstract

BACKGROUND:

Hyperpentaploidy in testicular nonseminomatous germ cell tumors (TNSGCT) has been associated with progression of disease of patients who initially had TNSGCT in Stage I.

METHODS:

The authors used flow cytometry to investigate the relationship between ploidy and the clinical behavior in TNSGCT, focusing on hypertetraploid values (DNA index, > 2.00).

RESULTS:

Patients with TNSGCT containing an aneuploid stemline with a hypertetraploid value more often had higher clinical stage of disease and a higher chance of relapse in advanced stages. The presence of multiple aneuploid stemlines in the tumors was found more frequently in patients who had higher clinical stage disease.

CONCLUSIONS:

The results suggest that the presence of highly aneuploid or multiple aneuploid stemlines in TNSGCT are associated with a clinically more malignant behavior.

PMID:
8393372
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Loading ...
    Write to the Help Desk