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    Biochim Biophys Acta. 1993 Jul 4;1149(2):189-94.

    Expression of alpha isoforms of the Na,K-ATPase in human heart.

    Zahler R, Gilmore-Hebert M, Baldwin JC, Franco K, Benz EJ Jr.

    Department of Internal Medicine, Yale University School of Medicine, New Haven, CT 06510.

    We studied expression of isoforms of Na,K-ATPase in normal and diseased human hearts. Na,K-ATPase alpha-isoform mRNA in samples from normal human left ventricle (LV) was composed of 62.5%, alpha 1, 15% alpha 2 and 22.5% alpha 3 on average. There was an increase in expression of the alpha 3 isoform in samples from failing hearts, but expression of all three isoforms decreased in pressure-overloaded right ventricle (RV).

    PMID: 8391840 [PubMed - indexed for MEDLINE]

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