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    Oncogene. 1993 Jul;8(7):2009-14.

    The human ryk cDNA sequence predicts a protein containing two putative transmembrane segments and a tyrosine kinase catalytic domain.

    Tamagnone L, Partanen J, Armstrong E, Lasota J, Ohgami K, Tazunoki T, LaForgia S, Huebner K, Alitalo K.

    Source

    Department of Pathology, University of Helsinki, Finland.

    Abstract

    The human ryk tyrosine kinase cDNA was originally identified as a PCR-amplified cDNA fragment (JTK5) from K562 leukemia cells and found to represent a ubiquitously expressed gene (Partanen et al., 1990). The open reading frame of human ryk, reported here, encodes a novel type of putative tyrosine kinase of 607 amino acid residues, having two potential transmembrane domains and homology to receptor tyrosine kinases, such as met (HGF/SF-R) and IGF-1R, in its catalytic domain. The gene maps to human chromosome 3q11-25. Expression of the 3.4 kb ryk mRNA was found in all human adult tissues examined.

    PMID:
    8390040
    [PubMed - indexed for MEDLINE]

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