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J Surg Oncol. 1993 Feb;52(2):77-82.

The effect of the fiber components cellulose and lignin on experimental colon neoplasia.

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  • 1Department of Surgery, University of Kentucky College of Medicine, Lexington.


Sixty Sprague-Dawley rats were pair-fed one of three nutritionally identical diets. One diet contained "low-fiber" (3.8% crude fiber); the others contained "high fiber" (28.7% crude fiber) composed of either cellulose or lignin. Although both "high fiber" diets had similar stool bulking effects, only the cellulose diet was associated with a reduction in 1,2-dimethylhydrazine (DMH)-induced colon neoplasms. The cellulose diet was also associated with distinct changes in the gut bacterial profile and with a lowered serum cholesterol.

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