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Science. 1993 Jan 22;259(5094):516-9.

Sequence and genome organization of a human small round-structured (Norwalk-like) virus.

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  • 1Department of Molecular Microbiology, University Medical School, Southampton General Hospital, United Kingdom.


Small round-structured viruses (SRSVs), also known as Norwalk or Norwalk-like viruses, are the major worldwide cause of acute, epidemic nonbacterial gastroenteritis in humans. These viruses, which contain a single-stranded RNA genome, have remained refractory to molecular characterization because of the small amounts of virus in clinical samples and the absence of an animal model and an in vitro culture system. The complete genomic nucleotide sequence of an SRSV, Southampton virus, was determined. The 7696-nucleotide RNA genome encodes three open reading frames whose sequences and organization strongly support proposals that SRVSs are members of the Caliciviridae.

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