Life Sci. 1993;52(1):1-8.

The combined immunological and antinociceptive defects of beige-J mice: the possible existence of a 'mu-repressin'.

Raffa RB, Mathiasen JR, Kimball ES, Vaught JL.

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Drug Discovery Research, R.W. Johnson Pharmaceutical Research Institute, PA 19477-0776.

Abstract

A selective non-responsiveness to the analgesic effects of opioid mu receptor-, but not opioid delta receptor-, mediated antinociception in the tail-flick test has been identified in C57BL/6J-bgJ (beige-J) mice. The beige-J mutation is also known to give rise to multiple immunological disorders and immune cell dysfunctions. A link between these apparently disparate manifestations has been examined in a series of studies using, for example, adoptive transfer of spleen cells. The findings appear to have broad implications for the link between the immune and opioid systems.

PMID:: 8380213; [PubMed - indexed for MEDLINE]

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