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Am J Psychiatry. 1993 Oct;150(10):1541-2.

Tricyclic dose requirements across pregnancy.

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  • 1Pregnancy and Infant/Parent Center, Western Psychiatric Institute and Clinic, University of Pittsburgh School of Medicine, PA 15213.


In a series of eight pregnant women, the authors found that the doses of tricyclic antidepressants required to achieve remission of symptoms and adequate serum levels increased during the second half of pregnancy. During the final trimester, the mean dose required was 1.6 times the mean dose required when the patients were not pregnant.

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