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Trends Genet. 1993 Jul;9(7):250-4.

The peculiar journey of a selfish chromosome: mouse t haplotypes and meiotic drive.

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  • 1Department of Molecular Biology, Princeton University, NJ 08544-1014.


Mouse t haplotypes are descendents of a variant form of chromosome 17 that evolved the ability to propagate itself at the expense of the wild-type homolog from heterozygous +/t males. Although once enigmatic, these widespread selfish chromosomes have revealed many of their secrets in response to a combined assault with molecular, genetic and phylogenetic techniques. This review summarizes the current understanding of t haplotypes and their raison d'ĂȘtre.

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