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Trends Genet. 1993 Jul;9(7):240-5.

Extinction of gene expression in somatic cell hybrids--a reflection of important regulatory mechanisms?

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  • 1Genecenter, Max Planck Institute for Biochemistry, Martinsried, Germany.

Abstract

Extinction in somatic cell hybrids is a multifactorial process that leads to loss of cell-type-specific gene expression. The underlying mechanisms are thought to mirror, at least in part, the repertoire of regulatory mechanisms controlling mammalian cell differentiation.

PMID:
8378999
[PubMed - indexed for MEDLINE]
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