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Cancer. 1993 Oct 1;72(7):2234-8.

A randomized clinical trial of two different durations of oral cryotherapy for prevention of 5-fluorouracil-related stomatitis.

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  • 1Illinois Oncology Research Association CCOP, Peoria.

Abstract

BACKGROUND:

The authors previously reported that 30 minutes of oral cryotherapy inhibits 5-fluorouracil (5-FU)-induced stomatitis. The current trial was designed to determine whether a longer duration of cryotherapy would provide additional protection.

METHODS:

This trial involved patients who were receiving their first course of a 5-FU plus leucovorin chemotherapy regimen, for which stomatitis is a major dose-limiting toxicity. These patients were randomized to receive either 30 or 60 minutes of oral cryotherapy given at around the same time as the 5-FU therapy.

RESULTS:

A total of 178 evaluable patients were studied. Both cryotherapy groups had similar degrees of mucositis.

CONCLUSION:

The authors continue to recommend the use of 30 minutes of oral cryotherapy for patients receiving bolus intensive courses of 5-FU-based chemotherapy.

PMID:
8374882
[PubMed - indexed for MEDLINE]
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