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    Acta Endocrinol (Copenh). 1993 Aug;129(2):97-108.

    Twin genes and endocrine disease: CYP21 and CYP11B genes.

    Helmberg A.

    Department of Molecular Biology, University of Innsbruck Medical School, Austria.

    CYP21 and CYP11B genes have a common feature: they are "twin" genes. It seems as if doubling and subsequent drifting apart rendered these genes particularly sensitive to defect acquisition by mechanisms involving recombinatorial events. This creates specific difficulties in the molecular diagnosis of defects.

    PMID: 8372604 [PubMed - indexed for MEDLINE]

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