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Br J Obstet Gynaecol. 1993 Jul;100(7):669-72.

Antithyroid antibodies underlying thyroid abnormalities and miscarriage or pregnancy induced hypertension.

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  • 1Department of Gynaecology and Obstetrics, Université Libre de Bruxelles, Belgium.

Abstract

OBJECTIVE:

To assess whether asymptomatic abnormalities, including thyroid auto-antibodies, were associated with an abnormal miscarriage rate or a poor obstetric outcome.

DESIGN:

Prospective study of thyroid auto-antibodies and thyroid function in an unselected obstetric population.

SETTING:

Saint-Pierrie Hospital, Brussels, Belgium.

SUBJECTS:

Seven hundred and thirty consecutive pregnant women attending the antenatal clinic.

MAIN OUTCOME MEASURES:

Miscarriage and pregnancy induced hypertension.

RESULTS:

Elevated antithyroperoxidase (TPO-Ab) and antithyroglobulin (TG-Ab) antibody titres are associated with an increased miscarriage rate. Also, asymptomatic thyroid abnormalities, mainly abnormal echo-structure but not antithyroid antibodies, are associated with pregnancy induced hypertension.

CONCLUSION:

The presence of thyroid auto-antibodies during pregnancy constitutes a marker of increased risk of miscarriage and poor obstetric prognosis.

Comment in

PMID:
8369252
[PubMed - indexed for MEDLINE]
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