Pharmacotherapy. 1993 Jul-Aug;13(4):406-7.

Can garlic lower blood pressure? A pilot study.

Source

Clinical Research Center, New Orleans, LA 70112.

Abstract

A popular garlic preparation containing 1.3% allicin at a large dose (2400 mg) was evaluated in this open-label study in nine patients with rather severe hypertension (diastolic blood pressure > or = 115 mm Hg). Sitting blood pressure fell 7/16 (+/- 3/2 SD) mm Hg at peak effect approximately 5 hours after the dose, with a significant decrease in diastolic blood pressure (p < 0.05) from 5-14 hours after the dose. No significant side effects were reported. Our results indicate that this garlic preparation can reduce blood pressure. Further controlled studies are needed, particularly with more conventional doses (e.g., < or = 900 mg/day), in patients with mild to moderate hypertension and under placebo-controlled, double-blind conditions.

PMID:: 8361870; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Medical

High Blood Pressure - MedlinePlus Health Information

Supplemental Content

Related citations

Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension. [Hypertens Res. 2009]
Time-released garlic powder tablets lower systolic and diastolic blood pressure in men with mild and moderate arterial hypertension.
Sobenin IA, Andrianova IV, Fomchenkov IV, Gorchakova TV, Orekhov AN. Hypertens Res. 2009 Jun; 32(6):433-7. Epub 2009 Apr 24.
Comparative antihypertensive effects of losartan 50 mg and losartan 50 mg titrated to 100 mg in patients with essential hypertension. [Blood Press. 1997]
Comparative antihypertensive effects of losartan 50 mg and losartan 50 mg titrated to 100 mg in patients with essential hypertension.
Ikeda LS, Harm SC, Arcuri KE, Goldberg AI, Sweet CS. Blood Press. 1997 Jan; 6(1):35-43.
Double-blind, randomized, multicentre comparison of the effects of amlodipine and perindopril on 24 h therapeutic coverage and beyond in patients with mild to moderate hypertension. General Physicians Investigators' Group. [J Hypertens. 1999]
Double-blind, randomized, multicentre comparison of the effects of amlodipine and perindopril on 24 h therapeutic coverage and beyond in patients with mild to moderate hypertension. General Physicians Investigators' Group.
Zannad F, Bernaud CM, Fay R. J Hypertens. 1999 Jan; 17(1):137-46.
Review Effect of garlic on blood pressure: a systematic review and meta-analysis. [BMC Cardiovasc Disord. 2008]
Review Effect of garlic on blood pressure: a systematic review and meta-analysis.
Ried K, Frank OR, Stocks NP, Fakler P, Sullivan T. BMC Cardiovasc Disord. 2008 Jun 16; 8:13. Epub 2008 Jun 16.
Review [Progress in the prevention and treatment of ischemic cerebrovascular diseases with garlic extract]. [Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995]
Review [Progress in the prevention and treatment of ischemic cerebrovascular diseases with garlic extract].
Zhang JL, Shi ZX, Zhang HY. Zhongguo Zhong Xi Yi Jie He Za Zhi. 1995 Feb; 15(2):124-6.

See reviews... See all...

Cited by 3 PubMed Central articles

Freshly crushed garlic is a superior cardioprotective agent than processed garlic. [J Agric Food Chem. 2009]
Freshly crushed garlic is a superior cardioprotective agent than processed garlic.
Mukherjee S, Lekli I, Goswami S, Das DK. J Agric Food Chem. 2009 Aug 12; 57(15):7137-44.
A review of studies of garlic (Allium sativum) on serum lipids and blood pressure before and after 1994: does the amount of allicin released from garlic powder tablets play a role? [J Chiropr Med. 2005]
A review of studies of garlic (Allium sativum) on serum lipids and blood pressure before and after 1994: does the amount of allicin released from garlic powder tablets play a role?
McRae MP. J Chiropr Med. 2005 Winter; 4(4):182-90.
Effect of garlic on cardiovascular disorders: a review. [Nutr J. 2002]
Effect of garlic on cardiovascular disorders: a review.
Banerjee SK, Maulik SK. Nutr J. 2002 Nov 19; 1:4. Epub 2002 Nov 19.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Can garlic lower blood pressure? A pilot study.
Can garlic lower blood pressure? A pilot study.
Pharmacotherapy. 1993 Jul-Aug ;13(4):406-7.

PubMed
Invasive lobular carcinomas of the breast--the prognosis of histopathological su...
Invasive lobular carcinomas of the breast--the prognosis of histopathological subtypes.
Br J Cancer. 1989 Oct ;60(4):605-9.

PubMed
Coelomic fat ectopia in the liver.
Coelomic fat ectopia in the liver.
Arch Pathol Lab Med. 1985 Aug ;109(8):783-5.

PubMed
Metastasizing basal cell carcinoma of the nipple.
Metastasizing basal cell carcinoma of the nipple.
Arch Pathol Lab Med. 1986 Aug ;110(8):761-2.

PubMed
Insect bites and stings.
Insect bites and stings.
Emerg Med Clin North Am. 1985 Nov ;3(4):785-808.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: