Glyoxalase II: molecular characteristics, kinetics...[Biochem Soc Trans. 1993]

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1: Biochem Soc Trans. 1993 May;21(2):522-7.Links

Glyoxalase II: molecular characteristics, kinetics and mechanism.

Vander Jagt DL.

Department of Biochemistry, University of New Mexico School of Medicine, Albuquerque 87131.

The mechanism that has been proposed for glyoxalase II [36] is summarized in Figure 3. It involves direct nucleophilic attack of an active-site histidine on the thiol ester substrate to form an acyl-imidazole intermediate which then rapidly hydrolyses. This is consistent with the known susceptibility of thiol esters to aminolysis and with the lability of acyl-imidazoles [47].

PMID: 8359524 [PubMed - indexed for MEDLINE]

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Glyoxalase II: molecular characteristics, kinetics and mechanism.

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