Is an activator protein-2-like transcription factor involved in regulating gene expression during nitrogen limitation in fungi?

Appl Environ Microbiol. 1993 Jul;59(7):2335-8. doi: 10.1128/aem.59.7.2335-2338.1993.

Abstract

The upstream sequences of all published lignin peroxidase and manganese peroxidase genomic clones from Phanerochaete chrysosporium were analyzed. This analysis revealed the presence of putative activator protein-2 (AP-2) recognition sequences in 11 of 15 lignin peroxidase genes. The lignin peroxidase clone GLG6 and the manganese peroxidase gene (mnp-1) have two copies of putative AP-2 sequence in the upstream region. Interestingly, the lignin peroxidase gene VLG4 of another white rot fungus, Trametes versicolor, and the nit-2 gene of Neurospora crassa also contain putative AP-2-binding sequences. Since all of these genes are regulated by nutrient nitrogen, I hypothesize that an AP-2-like transcription factor may be involved in inducing gene expression during nitrogen limitation in fungi.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Base Sequence
  • Basidiomycota / enzymology*
  • Basidiomycota / genetics
  • DNA-Binding Proteins / genetics*
  • Gene Expression Regulation, Enzymologic
  • Genes, Fungal / genetics*
  • Molecular Sequence Data
  • Nitrogen / deficiency
  • Peroxidases / genetics*
  • Transcription Factor AP-2
  • Transcription Factors / genetics*

Substances

  • DNA-Binding Proteins
  • Transcription Factor AP-2
  • Transcription Factors
  • Peroxidases
  • lignin peroxidase
  • manganese peroxidase
  • Nitrogen