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Neurology. 1993 Aug;43(8):1609-11.

Clinical trial of indomethacin in Alzheimer's disease.

Author information

  • 1L.J. Roberts Center for Alzheimer's Research, Sun Health Research Institute, AZ 85372.

Abstract

In a 6-month, double-blind, placebo-controlled study, 100 to 150 mg/d indomethacin appeared to protect mild to moderately impaired Alzheimer's disease patients from the degree of cognitive decline exhibited by a well-matched, placebo-treated group. Over a battery of cognitive tests, indomethacin patients improved 1.3% (+/- 1.8%), whereas placebo patients declined 8.4% (+/- 2.3%)--a significant difference (p < 0.003). Caveats include adverse reactions to indomethacin and the limited scale of the trial.

PMID:
8351023
[PubMed - indexed for MEDLINE]
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