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Biochim Biophys Acta. 1993 Aug 15;1150(2):130-3.

Induction of lipid-protein mismatch by xenobiotics with general membrane targets.

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  • 1Institut für Biochemische Pflanzenpathologie, GSF München, Neuherberg, Germany.


Many membrane-active xenobiotics, such as organic solvents or general anesthetics, are without specific target sites. A common, but as yet ill-defined physical mechanism of action is usually assumed. Displacement of 'boundary' lipid activators from functional membrane proteins by the induction of lipid/protein mismatch is now established as a candidate common physical mechanism. Multiple binding site kinetics demonstrate that xenobiotics can be strongly inhibitory at realistic membrane concentrations of below 4 mol%. A general equation for inhibition is derived.

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