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FEBS Lett. 1993 Aug 9;328(1-2):139-44.

Molecular cloning and developmental expression of human cardiac troponin T.

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  • 1University of Paris XI, CNRS URA 1159, Hôpital Marie Lannelongue, Le Plessis Robinson, France.


We have isolated a full-size cDNA coding for cardiac troponin T (cTnT) from a human adult heart library, using a slow skeletal TnT probe. This cDNA detected a 1.2 kb mRNA in fetal and post-natal human heart, the amount of which increased during ontogenic development. Interestingly, a similar transcript was coexpressed in fetal skeletal muscle, together with the 0.9 kb slow skeletal muscle mRNA, and its expression was down-regulated during further development.

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