Cell. 1993 Jul 30;74(2):299-307.

Crystal structure of the HhaI DNA methyltransferase complexed with S-adenosyl-L-methionine.

Cheng X, Kumar S, Posfai J, Pflugrath JW, Roberts RJ.

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W. M. Keck Structural Biology Laboratory, Cold Spring Harbor Laboratory, New York 11724.

Abstract

The first three-dimensional structure of a DNA methyltransferase is presented. The crystal structure of the DNA (cytosine-5)-methyltransferase, M.HhaI (recognition sequence: GCGC), complexed with S-adenosyl-L-methionine has been determined and refined at 2.5 A resolution. The core of the structure is dominated by sequence motifs conserved among all DNA (cytosine-5)-methyltransferases, and these are responsible for cofactor binding and methyltransferase function.

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Structures reported by this article

Crystal Structure Of The Hhai Dna Methyltransferase Complexed With S- Adenosyl-L-Methionine

PDB: 1HMY

Source: Haemophilus haemolyticus

Method: X-Ray Diffraction

Resolution: 2.5 Å

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Cell. 1993 Jul 30 ;74(2):299-307.

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