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Biochemistry. 1993 Jul 20;32(28):7065-8.

DNA photolyase repairs the trans-syn cyclobutane thymine dimer.

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  • 1Department of Biochemistry and Biophysics, University of North Carolina School of Medicine, Chapel Hill 27599.


DNA photolyases catalyze the splitting of the cyclobutane ring joining the two dihydropyrimidines of a pyrimidine dimer by a photoinduced electron-transfer reaction. Previous studies concluded that photolyase repairs only the cis-syn form of the eight stereoisomers of the cyclobutane pyrimidine dimer (Pyr[ ]Pyr). In this study we found that Escherichia coli photolyase binds to the trans-syn-I isomer of T[ ]T with about 10(4)-fold lower affinity than the cis-syn isomer but it repairs it relatively efficiently.

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