Selective and ATP-dependent translocation of pepti...[Science. 1993]

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1: Science. 1993 Aug 6;261(5122):769-71. Links

Erratum in:: Science 1994 Apr 1;264(5155):16.

Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter.

Neefjes JJ, Momburg F, Hämmerling GJ.

The Netherlands Cancer Institute, Amsterdam.

Major histocompatibility complex (MHC) class I molecules present peptides derived from nuclear and cytosolic proteins to CD8+ T cells. These peptides are translocated into the lumen of the endoplasmic reticulum (ER) to associate with class I molecules. Two MHC-encoded putative transporter proteins, TAP1 and TAP2, are required for efficient assembly of class I molecules and presentation of endogenous peptides. Expression of TAP1 and TAP2 in a mutant cell line resulted in the delivery of an 11-amino acid oligomer model peptide to the ER. Peptide translocation depended on the sequence of the peptide, was adenosine triphosphate (ATP)-dependent, required ATP hydrolysis, and was inhibited in a concentration-dependent manner.

PMID: 8342042 [PubMed - indexed for MEDLINE]

Evidence that transporters associated with antigen processing translocate a major histocompatibility complex class I-binding peptide into the endoplasmic reticulum in an ATP-dependent manner. [Proc Natl Acad Sci U S A. 1993]
Peptide size selection by the major histocompatibility complex-encoded peptide transporter. [J Exp Med. 1994]
TAP1-dependent peptide translocation in vitro is ATP dependent and peptide selective. [Cell. 1993]
ReviewMajor histocompatibility complex-linked transport proteins and antigen processing. [Immunol Res. 1992]
ReviewPeptide selection by MHC-encoded TAP transporters. [Curr Opin Immunol. 1994]

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Selective and ATP-dependent translocation of peptides by the MHC-encoded transporter.

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