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    Biochem Biophys Res Commun. 1993 Jul 15;194(1):496-503.

    cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily.

    Jin CJ, Miners JO, Lillywhite KJ, Mackenzie PI.

    Source

    Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, Australia.

    Abstract

    Two new UDP-glucuronosyltransferase cDNAs, designated UGT2B10 and UGT2B11, encoding 528 amino acid proteins were isolated from a human liver cDNA library. The deduced amino acid sequences of UGTs 2B10 and 2B11 share > 76% sequence similarity with other known human liver UGT2B subfamily isoforms and < 48% sequence similarity with UGT1 family proteins. COS-7 cells transfected with UGT 2B10 and 2B11 synthesized proteins with respective molecular masses of 49kDa and 51kDa. UGT2B11 expressed in COS-7 cells glucuronidated a number of polyhydroxylated estrogens (estriol, 4-hydroxyestrone and 2-hydroxyestriol) and xenobiotics (4-methylumbelliferone, 1-naphthol, 4-nitrophenol, 2-aminophenol, 4-hydroxybiphenyl and menthol). Despite the screening of more than forty potential substrates, glucuronidation activity was not observed for expressed UGT2B10.

    PMID:
    8333863
    [PubMed - indexed for MEDLINE]

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