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Nature. 1993 Jul 29;364(6436):412-20.

Co-crystal structure of the HNF-3/fork head DNA-recognition motif resembles histone H5.

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  • 1Laboratory of Molecular Biophysics, Rockefeller University, New York, New York 10021.


The three-dimensional structure of an HNF-3/fork head DNA-recognition motif complexed with DNA has been determined by X-ray crystallography at 2.5 A resolution. This alpha/beta protein binds B-DNA as a monomer, through interactions with the DNA backbone and through both direct and water-mediated major and minor groove base contacts, inducing a 13 degrees bend. The transcription factor fold is very similar to the structure of histone H5. In its amino-terminal half, three alpha-helices adopt a compact structure that presents the third helix to the major groove. The remainder of the protein includes a twisted, antiparallel beta-structure and random coil that interacts with the minor groove.

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