Proc Natl Acad Sci U S A. 1993 Jul 1;90(13):6071-5.

A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme.

Kok K, Hofstra R, Pilz A, van den Berg A, Terpstra P, Buys CH, Carritt B.

Source

Department of Medical Genetics, University of Groningen, The Netherlands.

Abstract

The chromosomal region 3p21 is thought to be the site of a lung tumor suppressor gene. We recently cloned a gene from this region that has greatly reduced expression in almost all lung tumor cell lines examined, in spite of being widely expressed in a variety of other tumor and nontumor cell types. We report here the sequence of this gene and show that it has significant homology to the genes encoding the ubiquitin-activating enzymes of three species, including humans. This suggests it is a second, autosomal member of this gene family in humans and may play a role in the ubiquitin conjugation pathway, which is of central importance in all eukaryotes.

PMID:: 8327486; [PubMed - indexed for MEDLINE]
PMCID:: PMC46869

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GENBANK/L13852

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A gene in the chromosomal region 3p21 with greatly reduced expression in lung ca...
A gene in the chromosomal region 3p21 with greatly reduced expression in lung cancer is similar to the gene for ubiquitin-activating enzyme.
Proc Natl Acad Sci U S A. 1993 Jul 1 ;90(13):6071-5.

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