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Mapping genes according to their amplification status in tumor cells: contribution to the map of 11q13.
LGMCH, CNRS URA 1462, Nice, France.
DNA amplification events that occur at 11q13 in human carcinomas are complex, and amplicons were shown to exhibit numerous discontinuities that could be used as tools for mapping this genomic area. A statistical nearest-neighbor analysis of the amplification patterns of several 11q13 loci in a panel of amplified DNAs was performed in the region of 11q13 centromeric from BCL1. It was strongly correlated with the physical linkages that we established between the same markers. Taken together, our results led to a map of 14 genes and four anonymous probes located in this area.
PMID: 8325649 [PubMed - indexed for MEDLINE]
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Cited by 2 PubMed Central articles
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Expression and gene amplification of primary (A, B1, D1, D3, and E) and secondary (C and H) cyclins in colon adenocarcinomas and correlation with patient outcome.
Bondi J, Husdal A, Bukholm G, Nesland JM, Bakka A, Bukholm IR.
J Clin Pathol. 2005 May; 58(5):509-14.
[J Clin Pathol. 2005]
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High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells.
Huang X, Gollin SM, Raja S, Godfrey TE.
Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11369-74. Epub 2002 Aug 9.
[Proc Natl Acad Sci U S A. 2002]