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    Gene. 1993 Jul 30;129(2):303-6.

    Sequence analysis reveals that the BTG1 anti-proliferative gene is conserved throughout evolution in its coding and 3' non-coding regions.

    Rouault JP, Samarut C, Duret L, Tessa C, Samarut J, Magaud JP.

    Source

    Equipe de Cytogénétique Moléculaire, Hôpital Edouard Herriot, Lyon, France.

    Abstract

    The human BTG1 gene (expressing an anti-proliferative function) is an evolutionarily conserved gene homologous to the murine PC3/TIS21 genes. Here, we report the cloning and sequencing of the murine BTG1 coding region and chicken BTG1 cDNA. The putative human and mouse BTG1 proteins are 100% identical; the chicken BTG1 cDNA contains an open reading frame of 170 amino acids with a 91% identity to its human and murine counterparts. The 3'-untranslated region of BTG1 is also highly conserved (82% homology between human and chicken), suggesting that it plays a key role in the regulation of BTG1 expression. These data confirm that BTG1 is phylogenetically highly conserved and that BTG1 and PC3/TIS21 may constitute the first members of a new family of functionally related genes.

    PMID:
    8325512
    [PubMed - indexed for MEDLINE]

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