Abstract
Encapsulation of amphotericin B in tuftsin-bearing liposomes greatly increased its efficacy in treatment of human aspergillosis in mice. Also, the drug efficacy was significantly increased by pretreating the animals with drug-free tuftsin-bearing liposomes. These results demonstrate that macrophage activation can considerably enhance the therapeutic efficacy of antifungal drugs, like amphotericin B.
Publication types
-
Research Support, Non-U.S. Gov't
MeSH terms
-
Amino Acid Sequence
-
Amphotericin B / administration & dosage*
-
Amphotericin B / therapeutic use
-
Animals
-
Aspergillosis / drug therapy*
-
Aspergillus fumigatus*
-
Drug Carriers
-
Humans
-
Liposomes
-
Macrophage Activation
-
Male
-
Mice
-
Mice, Inbred BALB C
-
Molecular Sequence Data
-
Tuftsin / administration & dosage*
-
Tuftsin / therapeutic use
Substances
-
Drug Carriers
-
Liposomes
-
Amphotericin B
-
Tuftsin