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Department of Health Studies, University of Waterloo, Ontario, Canada.
The effects of cell age on erythrocyte phospholipid fatty-acid composition and deformability were examined in 20 healthy adults (11 male, 9 female) prior to and following 12 weeks of dietary supplementation with 3.5 g/day of safflower oil (high in n - 6 fatty acids) or fish oil (high in n - 3 fatty acids). In the absence of dietary supplementation, old erythrocytes demonstrated an increase in filtration time (P < 0.001), an increase in membrane phospholipid total n - 6 fatty acids (P < 0.01), and a decrease in total n - 3/total n - 6 ratio (P < 0.01) compared to young erythrocytes. Both safflower and fish oil supplementation attenuated age-related differences in membrane phospholipid total n - 6 and total n - 3 fatty acids. Fish oil supplementation also increased the proportion of n - 3 fatty acids (P < 0.01) and the n - 3/n - 6 ratio (P < 0.05) in the phospholipids of both young and old erythrocytes, and eliminated age-related differences in erythrocyte filtration time by reducing the relative filtration time of the old erythrocytes.
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