Your browser version may not work well with NCBI's Web applications. More information here...
1: Genomics. 1993 May;16(2):520-3.Click here to read Links

The human C/EBP delta (CRP3/CELF) gene: structure and chromosomal localization.

Cleutjens CB, van Eekelen CC, van Dekken H, Smit EM, Hagemeijer A, Wagner MJ, Wells DE, Trapman J.

Department of Pathology, Erasmus University, Rotterdam, The Netherlands.

In an attempt to identify C/EBP-like transcription factors expressed in the prostate, a cDNA homologous to the mouse C/EBP delta (CRP3) and the rat CELF gene was isolated. A genomic clone containing the entire C/EBP delta gene was isolated using a cDNA fragment as a probe. The gene was characterized by restriction mapping and sequence analysis. By fluorescence in situ hybridization, using the biotinylated genomic clone as a probe, the C/EBP delta gene was assigned to the pericentromeric region of human chromosome 8, most probably to 8q11. This chromosomal localization was confirmed by analysis of a panel of human x hamster somatic cell hybrid DNA samples with a C/EBP delta-specific STS. As a result, the C/EBP delta gene could be positioned between the PLAT and the MOS loci.

PMID: 8314590 [PubMed - indexed for MEDLINE]

Related Articles