Can J Psychiatry. 1993 Nov;38 Suppl 4:S114-21.

A double-blind randomized clinical trial of rapid tranquilization with I.M. clonazepam and I.M. haloperidol in agitated psychotic patients with manic symptoms.

Chouinard G, Annable L, Turnier L, Holobow N, Szkrumelak N.

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Psychiatric Research Centre, Louis-H. Lafontaine Hospital, Montreal, Quebec.

Abstract

This double-blind clinical trial studied 16 acutely agitated psychotic patients with manic or manic-like symptoms who needed rapid tranquilization and were therefore on maintenance treatment. They were randomized to receive intramuscular preparations of clonazepam (1 to 2 mg) or haloperidol (5 to 10 mg) at 0, 0.5, and 1.0 hours. Both medications produced significant reduction of manic symptoms within two hours of initial treatment; however, haloperidol produced beneficial results more rapidly than clonazepam. All patients completed the study, with the exception of one haloperidol-treated patient who developed severe parkinsonism. It was concluded that I.M. clonazepam is an effective, safe, but slower-acting alternative to I.M. haloperidol in the treatment of agitated psychiatric patients in need of rapid tranquilization.

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Can J Psychiatry. 1994 Sep;39(7):451.

PMID:: 8306241; [PubMed - indexed for MEDLINE]

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A double-blind randomized clinical trial of rapid tranquilization with I.M. clonazepam and I.M. haloperidol in agitated psychotic patients with manic symptoms.

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