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Online J Curr Clin Trials. 1993 Dec 29;Doc No 110:[2002 words; 26 paragraphs].

Periventricular/intraventricular hemorrhage following early and delayed umbilical cord clamping. A randomized controlled trial.

Author information

  • 1Department of Obstetrics and Gynaecology, Coronation Hospital, Parktown, South Africa.

Abstract

OBJECTIVE:

To test the hypothesis that early compared with delayed clamping of the umbilical cords of low-birthweight babies may increase the incidence of periventricular/intraventricular hemorrhage (PVH/IVH).

DESIGN:

Randomized controlled trial.

SETTING:

The labor wards of 3 teaching hospitals of the University of the Witwatersrand, Johannesburg.

PATIENTS:

Women expected to give birth to babies weighing less than 2000 g.

INTERVENTIONS:

Allocation by randomly ordered, sealed cards to a policy either of clamping the umbilical cord immediately after delivery, or, if possible, delaying cord clamping for 1 to 2 min.

MAIN OUTCOME MEASURES:

Ultrasound diagnosis of PVH/IVH about 24 h after birth by an observer blind to the allocation of each patient.

RESULTS:

PVH/IVH was diagnosed in 8/40 (20%) of neonates following delayed umbilical cord clamping and 11/46 (24%) following early cord clamping (odds ratio 0.80; 95% confidence interval, 0.29 to 2.20).

CONCLUSIONS:

This study does not confirm that early clamping of the umbilical cord may contribute to the initiation of PVH/IVH in low-birthweight neonates, but further studies are required before the hypothesis can be rejected with confidence.

PMID:
8305996
[PubMed - indexed for MEDLINE]
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