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Am J Gastroenterol. 1994 Feb;89(2):208-13.

Establishment of a small animal model for human Helicobacter pylori infection using germ-free mouse.

Author information

  • 1First Department of Internal Medicine, Yamaguchi University, School of Medicine, Japan.

Abstract

OBJECTIVE:

To understand why oral inoculation of Helicobacter pylori resulted in continuous colonization of the stomach in germ-free athymic mice, but only temporary colonization in mice that were not germ-free.

METHODS:

We inoculated germ-free and "not-germ-free" euthymic mice with H. pylori and studied the resulting colonization of the stomach, comparing it against the germ-free athymic mouse model. In addition, we investigated Lactobacillus in the above-described three mouse groups.

RESULTS:

H. pylori were detected in all germ-free athymic mice and all germ-free euthymic mice continuously. However, in all euthymic mice that were not germ-free, H. pylori was detected only temporarily after inoculation. Lactobacilli were detected only in the not-germ-free mouse group. The number of H. pylori in the germ-free euthymic mice was significantly lower than in the germ-free athymic mice during the period of this study after inoculation.

CONCLUSIONS:

We therefore suggest that the growth of H. pylori may be suppressed by the immunological system and eradicated by Lactobacilli previously inhabiting the stomach.

Comment in

PMID:
8304305
[PubMed - indexed for MEDLINE]
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