Design and synthesis of inhibitors of folate-dependent enzymes as antitumor agents

Adv Exp Med Biol. 1993:338:387-408. doi: 10.1007/978-1-4615-2960-6_80.
No abstract available

Publication types

  • Comparative Study
  • Review

MeSH terms

  • Acyltransferases / antagonists & inhibitors
  • Animals
  • Antineoplastic Agents / chemical synthesis*
  • Antineoplastic Agents / therapeutic use
  • Antineoplastic Agents / toxicity
  • Drug Design
  • Folic Acid / analogs & derivatives
  • Folic Acid / chemical synthesis
  • Folic Acid / toxicity
  • Folic Acid Antagonists* / chemical synthesis*
  • Folic Acid Antagonists* / therapeutic use
  • Folic Acid Antagonists* / toxicity
  • Glutamates / chemical synthesis
  • Guanine / analogs & derivatives
  • Guanine / chemical synthesis
  • Humans
  • Hydroxymethyl and Formyl Transferases*
  • Indicators and Reagents
  • Molecular Structure
  • Pemetrexed
  • Phosphoribosylglycinamide Formyltransferase
  • Pyrroles
  • Quinazolines / chemical synthesis
  • Quinazolines / toxicity
  • Structure-Activity Relationship
  • Tetrahydrofolates / chemical synthesis

Substances

  • Antineoplastic Agents
  • Folic Acid Antagonists
  • Glutamates
  • Indicators and Reagents
  • Pyrroles
  • Quinazolines
  • Tetrahydrofolates
  • Pemetrexed
  • Guanine
  • lometrexol
  • CB 3717
  • Folic Acid
  • Hydroxymethyl and Formyl Transferases
  • Phosphoribosylglycinamide Formyltransferase
  • Acyltransferases