Trends Pharmacol Sci. 1993 Nov;14(11):413-8.

Agonist regulation of cellular G protein levels and distribution: mechanisms and functional implications.

Source

Department of Biochemistry, University of Glasgow, UK.

Abstract

Exposure of cells to agonists of receptors linked to G proteins can result in downregulation of cellular levels or redistribution of G proteins from membranes to the cytosol. Agonist-induced reductions in G protein levels have been observed for members of each of the Gs, Gi and Gq families of G proteins, are likely to be dependent upon the level of receptor expression, and are generally restricted to the G protein(s) with which the receptor interacts. The mechanisms responsible, reviewed here by Graeme Milligan, vary with cell type and include both second messenger-dependent and -independent enhanced protein degradation. Agonist-induced reduction in cellular G protein levels can provide one mechanism for the development of sustained heterologous desensitization.

PMID:: 8296400; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

Wellcome Trust/United Kingdom

Supplemental Content

Save items

Related citations in PubMed

Review Hormone-induced subcellular redistribution of trimeric G proteins. [Cell Mol Life Sci. 2002]
Review Hormone-induced subcellular redistribution of trimeric G proteins.
Svoboda P, Novotny J. Cell Mol Life Sci. 2002 Mar; 59(3):501-12.
Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in down-regulation of both the receptor and the alpha subunit of the G-protein Gq. [Biochem J. 1993]
Agonist activation of transfected human M1 muscarinic acetylcholine receptors in CHO cells results in down-regulation of both the receptor and the alpha subunit of the G-protein Gq.
Mullaney I, Dodd MW, Buckley N, Milligan G. Biochem J. 1993 Jan 1; 289 ( Pt 1):125-31.
Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit. [J Mol Cell Cardiol. 1997]
Ontogeny of regulatory mechanisms for beta-adrenoceptor control of rat cardiac adenylyl cyclase: targeting of G-proteins and the cyclase catalytic subunit.
Zeiders JL, Seidler FJ, Slotkin TA. J Mol Cell Cardiol. 1997 Feb; 29(2):603-15.
Reconstitution of beta2-adrenoceptor-GTP-binding-protein interaction in Sf9 cells--high coupling efficiency in a beta2-adrenoceptor-G(s alpha) fusion protein. [Eur J Biochem. 1998]
Reconstitution of beta2-adrenoceptor-GTP-binding-protein interaction in Sf9 cells--high coupling efficiency in a beta2-adrenoceptor-G(s alpha) fusion protein.
Seifert R, Lee TW, Lam VT, Kobilka BK. Eur J Biochem. 1998 Jul 15; 255(2):369-82.
Review Turning off the signal: mechanisms that attenuate signaling by G protein-coupled receptors. [Am J Physiol. 1997]
Review Turning off the signal: mechanisms that attenuate signaling by G protein-coupled receptors.
Grady EF, Böhm SK, Bunnett NW. Am J Physiol. 1997 Sep; 273(3 Pt 1):G586-601.

See reviews... See all...

Cited by 13 PubMed Central articles

Identification of a specific assembly of the g protein golf as a critical and regulated module of dopamine and adenosine-activated cAMP pathways in the striatum. [Front Neuroanat. 2011]
Identification of a specific assembly of the g protein golf as a critical and regulated module of dopamine and adenosine-activated cAMP pathways in the striatum.
Hervé D. Front Neuroanat. 2011; 5:48. Epub 2011 Aug 5.
Chronic morphine-induced changes in mu-opioid receptors and G proteins of different subcellular loci in rat brain. [J Pharmacol Exp Ther. 2002]
Chronic morphine-induced changes in mu-opioid receptors and G proteins of different subcellular loci in rat brain.
Fábián G, Bozó B, Szikszay M, Horváth G, Coscia CJ, Szücs M. J Pharmacol Exp Ther. 2002 Aug; 302(2):774-80.
Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha). [Br J Pharmacol. 2001]
Chronic systemic administration of salmeterol to rats promotes pulmonary beta(2)-adrenoceptor desensitization and down-regulation of G(s alpha).
Finney PA, Donnelly LE, Belvisi MG, Chuang TT, Birrell M, Harris A, Mak JC, Scorer C, Barnes PJ, Adcock IM, et al. Br J Pharmacol. 2001 Mar; 132(6):1261-70.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

Agonist regulation of cellular G protein levels and distribution: mechanisms and...
Agonist regulation of cellular G protein levels and distribution: mechanisms and functional implications.
Trends Pharmacol Sci. 1993 Nov ;14(11):413-8.

PubMed
Psychosocial implications of service dog ownership for people who have mobility ...
Psychosocial implications of service dog ownership for people who have mobility or hearing impairments.
Soc Work Health Care. 1993 ;19(1):109-25.

PubMed
Virtual reality in medicine.
Virtual reality in medicine.
Methods Inf Med. 1993 Nov ;32(5):407-17.

PubMed
Coffee-associated osteoporosis offset by daily milk consumption. The Rancho Bern...
Coffee-associated osteoporosis offset by daily milk consumption. The Rancho Bernardo Study.
JAMA. 1994 Jan 26 ;271(4):280-3.

PubMed
Technetium-99m-HMPAO SPECT, CT and MRI in the evaluation of patients with chroni...
Technetium-99m-HMPAO SPECT, CT and MRI in the evaluation of patients with chronic traumatic brain injury: a correlation with neuropsychological performance.
J Nucl Med. 1994 Feb ;35(2):217-26.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: