Ann Allergy. 1994 Jan;72(1):29-32.

Tolerability of nimesulide in aspirin-sensitive patients.

Andri L, Senna G, Betteli C, Givanni S, Scaricabarozzi I, Mezzelani P, Andri G.

Source

Allergology Unit, Main Hospital, Verona, Italy.

Abstract

In most patients with aspirin and nonsteroidal antiinflammatory drug (NSAID) intolerance, antiinflammatory treatment is a clinical problem. In this study we evaluated the tolerance to a new nonsteroidal antiinflammatory drug, nimesulide (Aulin, Boehringer Mannheim, Italia), in 429 patients presenting with clear histories of intolerance to NSAIDs. Nimesulide has been chosen due to its weak inhibitory action on cyclooxygenase and its peculiar mechanism of action. We carried out a single-blind challenge with cumulative doses of nimesulide administered on three different days, until the therapeutic dose of 200 mg or intolerance symptoms were reached. Nimesulide has been well tolerated in 418 subjects and only 11 patients (3.3%) showed a positive test. Our study demonstrates that nimesulide seems to be a suitable drug in aspirin hypersensitivity.

Comment in

PMID:: 8291746; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Medical

Molecular Biology Databases

ACETYLSALICYLIC ACID - HSDB

Supplemental Content

Save items

Related citations in PubMed

Safety of selective COX-2 inhibitors in aspirin/nonsteroidal anti-inflammatory drug-intolerant patients: comparison of nimesulide, meloxicam, and rofecoxib. [J Asthma. 2004]
Safety of selective COX-2 inhibitors in aspirin/nonsteroidal anti-inflammatory drug-intolerant patients: comparison of nimesulide, meloxicam, and rofecoxib.
Bavbek S, Celik G, Ozer F, Mungan D, Misirligil Z. J Asthma. 2004 Feb; 41(1):67-75.
The use of nimesulide in patients with acetylsalicylic acid and nonsteroidal anti-inflammatory drug intolerance. [J Asthma. 1999]
The use of nimesulide in patients with acetylsalicylic acid and nonsteroidal anti-inflammatory drug intolerance.
Bavbek S, Celik G, Ediger D, Mungan D, Demirel YS, Misirligil Z. J Asthma. 1999 Dec; 36(8):657-63.
Risk factors for acetaminophen and nimesulide intolerance in patients with NSAID-induced skin disorders. [Ann Allergy Asthma Immunol. 1999]
Risk factors for acetaminophen and nimesulide intolerance in patients with NSAID-induced skin disorders.
Asero R. Ann Allergy Asthma Immunol. 1999 Jun; 82(6):554-8.
Review Nimesulide in the treatment of patients intolerant of aspirin and other NSAIDs. [Drug Saf. 1996]
Review Nimesulide in the treatment of patients intolerant of aspirin and other NSAIDs.
Senna GE, Passalacqua G, Andri G, Dama AR, Albano M, Fregonese L, Andri L. Drug Saf. 1996 Feb; 14(2):94-103.
Review [Special features of NSAID intolerance in children]. [Allergol Immunopathol (Madr). ...]
Review [Special features of NSAID intolerance in children].
Porto Arceo JA. Allergol Immunopathol (Madr). 2003 May-Jun; 31(3):109-25.

See reviews... See all...

Cited by 3 PubMed Central articles

Clinical management of adult patients with a history of nonsteroidal anti-inflammatory drug-induced urticaria/angioedema: update. [Allergy Asthma Clin Immunol. 2...]
Clinical management of adult patients with a history of nonsteroidal anti-inflammatory drug-induced urticaria/angioedema: update.
Asero R. Allergy Asthma Clin Immunol. 2007 Mar 15; 3(1):24-30. Epub 2007 Mar 15.
Review The importance of COX-2 inhibition for aspirin induced asthma. [Thorax. 2000]
Review The importance of COX-2 inhibition for aspirin induced asthma.
Bennett A. Thorax. 2000 Oct; 55 Suppl 2:S54-6.
Enhanced expression of cyclo-oxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma. [Thorax. 1997]
Enhanced expression of cyclo-oxygenase isoenzyme 2 (COX-2) in asthmatic airways and its cellular distribution in aspirin-sensitive asthma.
Sousa A, Pfister R, Christie PE, Lane SJ, Nasser SM, Schmitz-Schumann M, Lee TH. Thorax. 1997 Nov; 52(11):940-5.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Tolerability of nimesulide in aspirin-sensitive patients.
Tolerability of nimesulide in aspirin-sensitive patients.
Ann Allergy. 1994 Jan ;72(1):29-32.

PubMed
An indirect negative autoregulatory mechanism involved in hepatocyte nuclear fac...
An indirect negative autoregulatory mechanism involved in hepatocyte nuclear factor-1 gene expression.
Nucleic Acids Res. 1993 Dec 25 ;21(25):5882-9.

PubMed
[Intestinal occlusion due to a colonic lipoma. Apropos 2 cases].
[Intestinal occlusion due to a colonic lipoma. Apropos 2 cases].
Minerva Chir. 1993 Sep 30 ;48(18):1035-9.

PubMed
The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerev...
The B subunit of the DNA polymerase alpha-primase complex in Saccharomyces cerevisiae executes an essential function at the initial stage of DNA replication.
Mol Cell Biol. 1994 Feb ;14(2):923-33.

PubMed
Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gen...
Transcription factor PRDII-BF1 activates human immunodeficiency virus type 1 gene expression.
J Virol. 1994 Feb ;68(2):1002-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: