Cloning of the cDNA (DSC1) coding for human type 1...[Genomics. 1993]

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1: Genomics. 1993 Nov;18(2):185-94. Links

Cloning of the cDNA (DSC1) coding for human type 1 desmocollin and its assignment to chromosome 18.

King IA, Arnemann J, Spurr NK, Buxton RS.

Laboratory of Eukaryotic Molecular Genetics, National Institute for Medical Research, Mill Hill, London, United Kingdom.

Desmosomes are adhesive epithelial junctions that contain two distinct classes of cadherin-related glycoproteins (desmogleins and desmocollins), both of which occur as several different isoforms whose expression is related to epithelial differentiation. We have now isolated cDNA clones encoding a human desmocollin that is expressed in the more differentiated layers of human epidermis. This isoform has 53% amino acid identity with the previously isolated human (type 3) desmocollin, which is expressed in the basal layers of the epidermis. However, the N- and C-termini of the mature proteins are more highly conserved. Using a panel of somatic cell hybrids, human type 1 desmocollin (gene DSC1) has been assigned to chromosome 18, the same location as the other desmocollin gene (DSC3) and the three desmoglein (DSG) genes already mapped.

PMID: 8288219 [PubMed - indexed for MEDLINE]

A YAC contig joining the desmocollin and desmoglein loci on human chromosome 18 and ordering of the desmocollin genes. [Genomics. 1997]
The desmocollins of human foreskin epidermis: identification and chromosomal assignment of a third gene and expression patterns of the three isoforms. [J Invest Dermatol. 1995]
Antisense expression of a desmocollin gene in MDCK cells alters desmosome plaque assembly but does not affect desmoglein expression. [Eur J Cell Biol. 1998]
Mouse desmocollin (Dsc3) and desmoglein (Dsg1) genes are closely linked in the proximal region of chromosome 18. [Genomics. 1994]
ReviewAnalysis of desmosomal cadherin-adhesive function and stoichiometry of desmosomal cadherin-plakoglobin complexes. [J Invest Dermatol. 1996]

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Cloning of the cDNA (DSC1) coding for human type 1 desmocollin and its assignment to chromosome 18.

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