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    Cytogenet Cell Genet. 1994;66(2):132-4.

    Assignment of the human PAX4 gene to chromosome band 7q32 by fluorescence in situ hybridization.

    Tamura T, Izumikawa Y, Kishino T, Soejima H, Jinno Y, Niikawa N.

    Department of Human Genetics, Nagasaki University School of Medicine, Japan.

    Of the nine known members of a human paired box-containing gene family (Pax), only PAX4 has not been precisely localized. We screened a cosmid library of human genomic DNA using polymerase chain reaction products for PAX4 as a probe and isolated three positive cosmid clones. Sequence analysis revealed that at least two of them had exon-like sequences and showed extensive homology to Pax-4 in the mouse. These two cosmid clones were mapped to human chromosome band 7q32 by fluorescence in situ hybridization.

    PMID: 8287686 [PubMed - indexed for MEDLINE]

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