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Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection.
Deutsches Krebsforschungszentrum, Heidelberg, Germany.
A transcription map covering a 300 kb region around the G6PD gene in the human Xq28 region was constructed by the direct cDNA selection method and the analysis of the resulting region-specific enriched cDNA sublibrary. Seven new genes and two loci of endogenous retrovirus HERV-K were identified. The distribution of the genes across the region is strongly non-uniform and follows the non-uniform distribution of GpG islands in the area. While one of the novel genes was found to be highly homologous to bovine smg p25A GDP-dissociation inhibitor, the remaining genes did not detect any homology to known genes. The analysis of region-specific cDNA sublibraries represents a simple, rapid and efficient tool for the generation of a regional transcription map.
PMID: 8281148 [PubMed - indexed for MEDLINE]
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Cited by 6 PubMed Central articles
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Novel transcripts discovered by mining genomic DNA from defined regions of bovine chromosome 6.
Weikard R, Goldammer T, Eberlein A, Kuehn C.
BMC Genomics. 2009 Apr 24; 10:186. Epub 2009 Apr 24.
[BMC Genomics. 2009]
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Human endogenous retrovirus (HERV-K) reverse transcriptase as a breast cancer prognostic marker.
Golan M, Hizi A, Resau JH, Yaal-Hahoshen N, Reichman H, Keydar I, Tsarfaty I.
Neoplasia. 2008 Jun; 10(6):521-33.
[Neoplasia. 2008]
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The systematic functional characterisation of Xq28 genes prioritises candidate disease genes.
Kolb-Kokocinski A, Mehrle A, Bechtel S, Simpson JC, Kioschis P, Wiemann S, Wellenreuther R, Poustka A.
BMC Genomics. 2006 Feb 17; 7:29. Epub 2006 Feb 17.
[BMC Genomics. 2006]
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