Chromosomal localization of two genes encoding human ras exchange factors: SOS1 maps to the 2p22-->p16 region and SOS2 to the 14q21-->q22 region of the human genome

P Chardin; M G Mattei

doi:10.1159/000133667

Chromosomal localization of two genes encoding human ras exchange factors: SOS1 maps to the 2p22-->p16 region and SOS2 to the 14q21-->q22 region of the human genome

Cytogenet Cell Genet. 1994;66(1):68-9. doi: 10.1159/000133667.

Authors

P Chardin¹, M G Mattei

Affiliation

¹ Institut de Pharmacologie Moleculaire et Cellulaire du CNRS, Valbonne, France.

PMID: 8275713
DOI: 10.1159/000133667

Abstract

The human SOS1 and SOS2 genes encode proteins that control GDP-->GTP exchange on ras proteins and are involved in signal transduction by tyrosine kinase receptors. In situ hybridization shows that SOS1 maps to 2p22-->p16 and SOS2 to 14q21-->q22 in the human genome.

MeSH terms

Chromosome Banding
Chromosome Mapping
Chromosomes, Human, Pair 14*
Chromosomes, Human, Pair 2*
Cloning, Molecular
Genes, ras*
Genome, Human*
Humans
In Situ Hybridization
Membrane Proteins / genetics*
Plasmids
Son of Sevenless Proteins

Substances

Membrane Proteins
Son of Sevenless Proteins