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    Science. 1994 Jan 7;263(5143):92-5.

    Association and activation of Jak-Tyk kinases by CNTF-LIF-OSM-IL-6 beta receptor components.

    Stahl N, Boulton TG, Farruggella T, Ip NY, Davis S, Witthuhn BA, Quelle FW, Silvennoinen O, Barbieri G, Pellegrini S, et al.

    Source

    Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591.

    Abstract

    A recently defined family of cytokines, consisting of ciliary neurotrophic factor (CNTF), leukemia inhibitory factor (LIF), oncostatin M (OSM), and interleukin-6 (IL-6), utilize the Jak-Tyk family of cytoplasmic tyrosine kinases. The beta receptor components for this cytokine family, gp130 and LIF receptor beta, constitutively associate with Jak-Tyk kinases. Activation of these kinases occurs as a result of ligand-induced dimerization of the receptor beta components. Unlike other cytokine receptors studied to date, the receptors for the CNTF cytokine family utilize all known members of the Jak-Tyk family, but induce distinct patterns of Jak-Tyk phosphorylation in different cell lines.

    PMID:
    8272873
    [PubMed - indexed for MEDLINE]

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