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Acta Gastroenterol Belg. 1993 May-Aug;56(3-4):292-5.

Repeated hepatic ischemia in combination with chemotherapy for liver carcinoid metastases.

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  • 1Department of Gastroenterology, University Hospital Gasthuisberg, Leuven, Belgium.


Both hepatic ischemia and chemotherapy are effective in the treatment of carcinoid liver metastases, but their effectiveness is often limited, partial and transient. It has been shown that, during intermittent occlusion of the hepatic artery with a surgically implanted occluder, no revascularisation from collaterals occurs. We studied the feasibility, the side-effects, the response to tumour measurements and hormonal excretions of a combined treatment of repeated hepatic ischemia and 5-Fluorouracil and Streptozotocin-administration in carcinoid liver metastases.

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